Web of knowledge for

IDEAS – NANOMED

Contract number 257/2011

National Authority: UEFISCDI

UNIVERSITATEA BABES BOLYAI

FACULTATEA DE CHIMIE SI INGINERIE CHIMICA

 

Multifunctional nanostructures formed of gold or silver nanoparticles and different biomolecules with medical applications - NANOMED

 

Nanostructuri multifuncţionale formate din nanoparticule de aur sau argint şi diferite biomolecule cu aplicaţii medicale - NANOMED 

 

 

 

 

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OBJECTIVES

EXPECTED IMPACT

OBTAINED RESULTS

TEAM

DISSEMINATION

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

·   Dissemination

♦articles, ♦communications, ♦monograph, ♦patent application; ♦Completion of PhD theses, ♦graduation theses. 

·   Research original articles

 

1) Gh. Tomoaia, P. T. Frangopol, O. Horovitz, L.-D. Bobos, A. Mocanu, M. Tomoaia-Cotisel,

“The effect of arginine on gold nanoparticles in colloidal solutions and in thin films”,

Journal of Nanoscience and Nanotechnology, 11(9), 7762-7770 (2011).

 

2) U. V. Zdrenghea, Gh. Tomoaia, D.-V. Pop-Toader, A. Mocanu, O. Horovitz, M. Tomoaia-Cotisel,

“Procaine effect on human erythrocyte membrane explored by atomic force microscopy”,

Combinatorial Chemistry & High Throughput Screening, 14 (4), 237-247 (2011).

 

3) M. Tomoaia-Cotisel, R.-D. Pasca, O. Horovitz, A. Mocanu,

“Surface potentials of cholesterol and dimyristoyl phosphatidylcholine monolayers at the air/water interface”,

Rev. Roum. Chim., 56(10-11), 1047-1053 (2011).

 

4) Cs. P. Racz, R.-D. Pasca, S. Santa, I. Kacso, Gh. Tomoaia, A. Mocanu, O. Horovitz, M. Tomoaia-Cotisel,

“Inclusion complex of β-cyclodextrin and quercetin. Thermodynamic approach”,

Rev. Chim. (Bucharest), 62(10), 992-997 (2011).

 

5) Cs. P. Racz, G. Borodi, M.M. Pop, I. Kacso, S. Santa, M. Tomoaia-Cotisel,

“Structure of the inclusion complex of β-cyclodextrin with lipoic acid from laboratory powder diffraction data”,

Acta Cryst., B68, 164-170 (2012).

 

6) Cs-P. Racz, Sz. Santa, M. Tomoaia-Cotisel, Gh. Borodi, I. Kacso, A. Pirnau, I. Bratu,

“Inclusion of α-lipoic acid in β-cyclodextrin. Physical-chemical and structural characterization”,

J. Incl. Phenom. Macrocycl. Chem., 76(1), 193-199 (2013).  2012:  DOI: 10.1007/s10847-012-0191-z.

 

7) F. Popa, P. Lameiras, O. Moldovan, M. Tomoaia-Cotisel, E. Henon, A. Martinez, C. Sacalis, A. Mocanu, Y. Ramondenc, M. Darabantu,

 “Design, synthesis and structure of new dendritic melamines”,

Tetrahedron, 68, 8945-8967 (2012).

 

8) A. Mocanu, R.-D. Pasca, Gh. Tomoaia, A. Avranas, O. Horovitz, M. Tomoaia-Cotisel,

“Selective Effect of Procaine, Tetracaine and Dibucaine on Gold Nanoparticles”,

J. Nanosci. Nanotechnol., 12, 1-5 (2012).

 

9) M. Vlassa, V. Coman, M. Filip, F. Copaciu, A. Mocanu, M. Tomoaia-Cotisel,

”OPLC separation and identification of some amino acids from different matrices”,

Journal of Planar Chromatography - Modern TLC, 26 (1), 1-14, 2013.

 

10) G. Furtos, M. Tomoaia-Cotisel, C. Garbo, M. Şenilă, N. Jumate, I. Vida-Simiti, C. Prejmerean,

“New composite bone cement based on hydroxyapatite and nanosilver,

Particul. Sci. Technol., 31, 392-398 (2013).   DOI: 10.1080/02726351.2013.767293.

 

11) A. Mocanu, R.-D. Pasca, Gh. Tomoaia, C. Garbo, P. T. Frangopol, O. Horovitz, M. Tomoaia-Cotisel,

New procedure to synthesize silver nanoparticles and their interaction with local anesthetics”,

Int. J. Nanomedicine, 8, 3867-3874 (2013).

 

12) R.-D. Pasca, A. Mocanu, S.-C. Cobzac, I. Petean, O. Horovitz, M. Tomoaia-Cotisel,

“Biogenic syntheses of gold nanoparticles using plant extracts”,

Particul. Sci. Technol., 32(2), 131-137 (2014); DOI: 10.1080/02726351.2013.839589.

 

13) A. Mocanu, G. Furtos, S. Rapuntean, O. Horovitz, C. Flore, C. Garbo, A. Danisteanu, Gh. Rapuntean, C. Prejmerean, M. Tomoaia-Cotisel,

 “Synthesis, characterization and antimicrobial effects of composites based on multi-substituted hydroxyapatite and silver nanoparticles”,

Appl. Surf. Sci., 298, 225–235 (2014).

 

14) P.T. Frangopol. D. A. Cadenhead, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel,

“The effect of procaine on lipid domains investigated by contact mode atomic force microscopy”,

Rev. Roum.Chim., 60(2-3), 265-273 (2015).

 

15) A. Mocanu, O. Horovitz, Cs. P. Racz, M. Tomoaia-Cotisel,

“Green synthesis and characterization of gold and silver nanoparticles”,

Rev. Roum. Chim., 60(7-8), 721-726 (2015).

 

16) Gh. Tomoaia, O. Horovitz, A. Mocanu, A. Nita, A. Avram, C.P. Racz, O. Soritau, M. Cenariu, M. Tomoaia-Cotisel,

“Effects of doxorubicin mediated by gold nanoparticles and resveratrol in two human cervical tumor cell lines”,

Colloids and Surfaces B: Biointerfaces, 135, 726-734 (2015).

 

·   Communications at workshops and meetings on nano-materials and nano-scale architectures

 

C1) M. Tomoaia-Cotisel,

“Biocomposites formed by nano hydroxyapatite, its various substitutes and different polymers and their applications”,

Humboldt-Kolleg, Cooperation and networking of universities and research institutes, “Study by doing research, - Material physics and nanomaterials -   NANO-2011,  Chişinău, Moldova, 6 –10 October 2011.

 

C2) Gh. Tomoaia, L.-B. Pop, O. Soritau, M. Tomoaia-Cotisel,

“The effect of nano and microstructures on osteoblasts behavior and collagen cells production”,

- Cost Action TD0903 - “The 3rd workshop and 4th management meeting – understanding and manipulating enzymatic and proteomic processes in biomineralization – towards new biomimetic strategies, the creation of tailored nano-scale architectures and environmental monitoring”, Cluj-Napoca, 11-13 October, 2011.

 

C3) M.A. Naghiu, M. Gorea, D. M. Ungvari, M. Tomoaia-Cotisel,

“Preparation, characterization and medical applications of some ceramics based on forsterite”,

- Cost Action TD0903 - “The 3rd workshop and 4th management meeting – understanding and manipulating enzymatic and proteomic processes in biomineralization – towards new biomimetic strategies, the creation of tailored nano-scale architectures and environmental monitoring”, Cluj-Napoca, 11-13 October, 2011.

 

C4) Gh. Tomoaia, L.-B. Pop, G. Furtos, C. Prejmerean, I. Petean, R.-D. Pasca, A.-G. Hosu-Prack, A. Mocanu, M. Tomoaia-Cotisel,

The effect of various calcium phosphate particles on collagen mineralization

- Cost Action TD0903 - “The 3rd workshop and 4th management meeting – understanding and manipulating enzymatic and proteomic processes in biomineralization – towards new biomimetic strategies, the creation of tailored nano-scale architectures and environmental monitoring”, Cluj-Napoca, 11-13 October, 2011.

 

C5) M. Tomoaia-Cotisel, A. Mocanu,

“Monolayers of aleurone protein and lipids at interfaces”,

Langmuir Blodgett self-assembled monolayers, LBT Conference”, Paris, France, July 10-13, 2012.

 

C6) A. Tomoaia-Cotisel, M. Tomoaia-Cotisel,

Nanostructure of collagen fibres explored by AFM and SEM”,

“Langmuir Blodgett self-assembled monolayers, LBT Conference”, Paris, France, July 10-13, 2012.

 

C7) A. Mocanu, R.D. Pasca, Gh. Tomoaia, O. Horovitz, M. Tomoaia-Cotisel,

“Structural and thermodynamic characterization of cholesterol and dimyristoyl phosphatidyl choline monolayers at the air/water interface”,

Langmuir Blodgett self-assembled monolayers, LBT Conference”, Paris, France, July 10-13, 2012. 

 

C8) R. D. Pasca, A. Mocanu, Gh. Tomoaia, O. Horovitz, M. Tomoaia-Cotisel,

”Membrane models. The interaction between lipids and proteins”,

”The 32nd National Conference of  Chemistry, Căciulata, Romania, October 3 - 5, 2012.

 

C9) Gh. Tomoaia, A.-G. Hosu-Prack, I. Petean, A. Mocanu, M. Tomoaia-Cotisel,

“The effect of hydroxyapatite nanoparticles on collagen mineralization”,

Scientific meeting of COST Action TD0906, Cluj-Napoca,  9 -11 April 2013. 

 

C10) Sz. Santa, Cs-P. Racz, M. Tomoaia-Cotisel,

“Inclusion mechanism of lipoic acid into cyclodextrin”,

Scientific meeting of COST Action TD0906, Cluj-Napoca,  9 -11 April 2013.

 

C11) R.D. Pasca, D. Frankel,

“Interaction of lipids with lectins”,

Scientific meeting of COST Action TD0906, Cluj-Napoca,  9 -11 April 2013.

 

C12) C. Prejmerean, C.-L. Garbo, I.M. Hodisan, A. Danistean, I. Petean, A. Mocanu, G. Furtos, M. Tomoaia-Cotisel,

Surface characterization of some bioadhesives with potential applications in medicine. AFM investigation”,

The 11th Conference on Colloid and Surface Chemistry, Iasi, Romania, May 9-11, 2013.

 

C13) A. M. Budaca, A. I. Gog, A. Mocanu, Gh. Tomoaia, L. D. Bobos, M. Tomoaia-Cotisel,

“Multifunctional biomaterials based on hydroxyapatite and collagen type 1 with potential applications in medicine”,

The 11th Conference on Colloid and Surface Chemistry, Iasi, Romania, May 9-11, 2013.

 

C14) M. Tomoaia-Cotisel,

“Quarter century progress and new horizons in Cluj-Napoca colloid science. From multifunctional bio-interfaces and self-assembled monolayers to nanostructured biomaterials”,

The 11th Conference on Colloid and Surface Chemistry, Iasi, Romania, May 9-11, 2013.

 

C15) R.-D. Pasca, A. Mocanu, Gh. Tomoaia, O. Horovitz, M. Tomoaia-Cotisel,

“Interaction between lipids and collagen type I”,

The 11th Conference on Colloid and Surface Chemistry, Iasi, Romania, May 9-11, 2013.

 

C16) M.-A. Naghiu, M. Gorea, Gh. Tomoaia, G. Furtos, A. Mocanu, M. Tomoaia-Cotisel,

“Synthesis and characterization of forsterite enriched in nano silver”, 

The 11th Conference on Colloid and Surface Chemistry, Iasi, Romania, May 9-11, 2013.

  

C17) R.D. Pasca, M. Tomoaia-Cotisel and Gh. Tomoaia,

“The formation and characterization of collagen fibers at the air water interface”,

The 6th International Conference “Biomaterials, Tissue Engineering & Medical Devices” (BiomMedD’2014),

Constanta, Romania, September 17-20, 2014; http://biommedd2014.srb.ro/

 

C18) R.D. Pasca, Gh. Tomoaia, A. Mocanu, I. Petean, A.G. Hosu-Prack and M. Tomoaia-Cotisel,

“Fibrous Structures of Collagen Type I Investigated by Langmuir-Blodgett Technique and AFM”,

The 5th Conference on Advanced Spectroscopies on Biomedical and Nanostructured Systems (BioNanoSpec 2014),

Cluj-Napoca, Romania, September 7-10, 2014;  http://icei.ubbcluj.ro/bionanospec/

 

C19) Gh. Tomoaia, A. Tomoaia-Cotisel, A. Mocanu, M. Tomoaia-Cotisel

“Innovative hydroxyapatites, collagen and chitosan scaffolds for enhanced adhesion, growth and bioactivity of human osteoblasts in vitro”,

“The 20th International Conference on Composite Materials: ICCM20”, Copenhagen, 19-24 July, 2015.

 

C20) R. D. Pasca, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel,

"Biomimetic collagen scaffolds for cell cultures",

“The 10th International Conference - Processes in Isotopes and Molecules", Cluj-Napoca, 23-25 September, 2015.

 

·   Ph D. Thesis

 

T1) R.D. Pasca,

“Lipid nanostructures in the presence of some water soluble biomolecules or of metallic gold or silver nanoparticles”,

PhD Thesis, Babes-Bolyai University of Cluj-Napoca, 2013.

 

T2) A. Nita,

"Gold or silver nanoparticles functionalized with biomolecules. Biomedical applications”,

PhD Thesis, Babes-Bolyai University of Cluj-Napoca, in progress.

 

T3) A. Avram,

“Research and development of some nanostructured systems of biological and biomedical interest”,

PhD Thesis, Babes-Bolyai University of Cluj-Napoca, in progress.

 

T4) Sz. Santa,

“Research and development of some micro- and nano-structured systems made from various biomolecules”,

PhD Thesis, in progress, Babes-Bolyai University of Cluj-Napoca, in progress.