STAGES
OBJECTIVE 1. THE SYNTHESIS OF VARIOUS (HETERO)ARYL
-ETHYLAMINES, -HYDROXY-PROPANOATES
AND –ALANINES AS WELL
THEIR RESOLUTION COUNTERPARTS
WP1. Chemical synthesis of various racemic
compounds
|
WP2.
Development of analytical scale enantiomeric
separations OBJECTIVE
2. KINETIK RESOLUTION OF THE
RACEMATES WP1.
Investigation of the kinetic resolution of various racemates OBJECTIVE 3. BIOCATALYTIC PROCEDURES WITH
“ANTI-KAZLAUSKAS” ENZYMES WP1. Fermentation and enzyme activity
screening for potential anti-Kazlauskas” enzymes WP2. Isolation and purification of
enzymes WP3.
Activity and selectivity test of the isolated homogene
fractions OBJECTIVE 4. IMMOBILIZATION OF LIPASES WP1. The development of
various enzyme immobilization methods WP2. The selection useful
immobilized enzymes WP3. Reusability of the
biocatalysts OBJECTIVE 5. THE DEVELOPMENT OF THE DKR PROCESSES WP1. Selection of the proper racemizing agent
WP2. Optimization of the
batch DKR OBJECTIVE 6. CONTINUOUS
FLOW DKR WP1. Determination of racemizing
agent/biocatalyst ratio WP2. Continuous flow DKR with arrayed
plug flow reactors WP3. Continuous flow DKR with parallel
plug flow reactors |
|
