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Abstract

Objectives

Stages

Research team

Results

 

STAGES

OBJECTIVE 1. THE SYNTHESIS OF VARIOUS (HETERO)ARYL -ETHYLAMINES, -HYDROXY-PROPANOATES

AND –ALANINES AS WELL THEIR RESOLUTION COUNTERPARTS

WP1. Chemical synthesis of various racemic compounds

WP2. Development of analytical scale enantiomeric separations

 

OBJECTIVE 2. KINETIK RESOLUTION OF THE RACEMATES

WP1. Investigation of the kinetic resolution of various racemates

 

OBJECTIVE 3. BIOCATALYTIC PROCEDURES WITH “ANTI-KAZLAUSKAS” ENZYMES

WP1. Fermentation and enzyme activity screening for potential anti-Kazlauskas” enzymes

WP2. Isolation and purification of enzymes

WP3. Activity and selectivity test of the isolated homogene fractions

 

OBJECTIVE 4. IMMOBILIZATION OF LIPASES

WP1. The development of various enzyme immobilization methods

WP2. The selection useful immobilized enzymes

WP3. Reusability of the biocatalysts

 

OBJECTIVE 5. THE DEVELOPMENT OF THE DKR PROCESSES

WP1. Selection of the proper racemizing agent

WP2. Optimization of the batch DKR

 

OBJECTIVE 6. CONTINUOUS FLOW DKR

WP1. Determination of racemizing agent/biocatalyst ratio

WP2. Continuous flow DKR with arrayed plug flow reactors

WP3. Continuous flow DKR with parallel plug flow reactors