Research team





Scientific report on stage I



Scientific report on stage II

Results dissemination

  1. Mara Ana Naghi, László Csaba Bencze, Jürgen Brem, Csaba Paizs, Florin Dan Irimie, Monica Ioana Tosa: Sequential enzymatic procedure for the preparation of enantiomerically pure 2-heteroaryl-2-hydroxyacetic acids Tetrahedron: Asymmetry 2012, 23, 181-187 (Abstract)
  2. Laura Pop, Pierrik Lassalas, László Csaba Bencze, Monica Ioana Tosa, Botond Nagy, Florin Dan Irimie, Christophe Hoarau: Chemoenzymatic synthesis of highly enantiomerically enriched secondary alcohols with a thiazolic core Tetrahedron: Asymmetry 2012, 23, 474-481 (Abstract)
  3. Jürgen Brem, László-Csaba Bencze, Arto Liljeblad, Mihaela C. Turcu, Csaba Paizs, Florin-Dan Irimie, Liisa T. Kanerva: Chemoenzymatic preparation of 1-heteroarylethanamines of low solubility Eur. J. Org. Chem. 2012, 17, 3288-3294 (Abstract)



Scientific report on stage III

 Scientific report 2011-2013

Results dissemination

1. Botond NAGY, Norbert DIMA, Monica Ioana TOȘA, Csaba PAIZS, Florin Dan IRIMIE: Alternative approaches for the enantioselective synthesis of (R)- and (S)-Bufuralol,13th Symposium and Summer School on Bioanalysis (13th ISSSB), 27-7 July 2013, Debrecen, Hungary (Poster)

2. Mara NAGHI, Judith VARI, Monica Ioana TOSA, Csaba PAIZS, Florin-Dan IRIMIE: CaL-A mediated kinetic resolution of racemic 2-hydroxy-2-(5-phenylthiophene-2-yl)acetonitrile and its derivatives, 13th Symposium and Summer School on Bioanalysis (13th ISSSB), 27-7 July 2013, Debrecen, Hungary (Poster)



Scientific report on stage IV

Results dissemination

Scientific articles

1.     Alexandra Radu, Mădălina Elena Moisă, Monica Ioana Toșa, Norbert Dima,Valentin Zaharia, Florin Dan Irimie: Candida antarctica lipases acting as versatile catalysts for the synthesisof enantiopure (R)- and (S)-1-(2-phenylthiazol-4-yl)ethanamines, Journal of Molecular Catalysis B: Enzymatic 2014, 107, 114–119 (Abstract)

2.     Gergely N. Nagy, Livia Marton, Alicia Contet, Oliver Ozohanics, Laura-Mihaela Ardelean, Agnes Revesz, Karoly Vekey, Florin Dan Irimie, Henri Vial, Rachel Cerdan, and Beata G. Vertessy: Composite Aromatic Boxes for Enzymatic Transformations of Quaternary Ammonium Substrates, Angew. Chem. 2014, 126, 13689 –13694; (Abstract)

International conferences

1. Florin Dan Irimie, Csaba Paizs, Monica Ioana Toșa: Enzymatic Chiral Resolutions and Chromatographic Monitoring - New Insights, lecture at 14th International Symposium and Summer School on Bioanalysis, Bratislava – Smolenice, 28 June – 6 July 2014, L26 (Abstract)

2. Mădălina Elena Moisă, Csaba Paizs, Monica Ioana Toşa, Florin Dan Irimie, CaL-A-mediated synthesis of benzofuranyl-β-amino acid derivatives, Innovative Materials and Processes, 2nd International Conference on Chemical Engineering, ICCE 2014, 5-8 November 2014, Iasi, Romania (Abstract)



Scientific report on stage V


Scientific articles

1.   Denisa Leonte, László Csaba Bencze, Csaba Paizs, Monica Ioana Tosa, Valentin Zaharia, Florin Dan Irimie: Heterocycles 36. Single walled carbon nanotubes bound N,N-diethylethanolamine as mild and efficient racemization agent in the enzymatic DKR of 2-arylthiazol-4-yl-alanine, Molecules, 2016, 21(1), 25-40 (Abstract)



1. Mara Naghi, Csaba Paizs, Monica Ioana Toșa, Florin Dan Irimie,: Medium engineering in the enzymatic kinetic resolutions mediated by lipases, 15th International Symposium and Summer School on Bioanalysis, (Poster) 13-18 July 2015, Tg. Mures, Romania



Scientific report on stage VI


Scientific articles

1. Matthias Granold, Parvana Hajieva, Monica Tosa, Florin-Dan Irimie, Bernd Moosmann: Chemical reactivity, molecular oxygen and modern genetic code, PNAS, 2016, submitted (Abstract)


1. Florin Dan Irimie: Chemistry and genetic code, 16th International Symposium and Summer School on Bioanalysis, (Oral presentation) 6-15 July 2016, Warsaw, Poland


Scientific report 2011-2016