Research team



The main objective of the present proposal is to achieve new enzymatic DKR procedures for the enantioselective synthesis of both enantiomers of alfa- and beta-aryl-alanines, aryl-amines and aryl-hydroxy-propanoates using batch and continuous flow procedures. For the successful execution of the project the biocatalytic potential of several lipases will be investigated. Moreover, the selection strains which could produce hydrolases with opposite selectivity will be taking into consideration. The production, purification, characterization and immobilization of such kind of (S)-selective enzymes together with other know (R)-selective lipases will allow the elaboration of efficient batch DKR procedures. The found optimal conditions will be the prerequisite for building various types of continuous flow procedures for a more efficient production of various enantiopure chiral building blocks.