Web of knowledge for

INA - MAT

Contract number PCE 186 /2021

National Authority: UEFISCDI

UNIVERSITATEA BABES BOLYAI

FACULTATEA DE CHIMIE SI INGINERIE CHIMICA

 

Innovative strategies for safe production of advanced materials based on multifunctional ceramic and metallic nanoparticles for medical applications (INA-MAT)
Strategii inovative de producere a unor materiale avansate pe baza de nanoparticule, ceramice si metalice, multifunctionale pentru aplicatii medicale,
INA-MAT
 

 

 

 

 

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OBJECTIVES

EXPECTED RESULTS

OBTAINED RESULTS

DISSEMINATION

 

 

 

 

 

 

·   Phase 1 Dissemination:

• Research original articles (ISI)

1. D. Oltean-Dan, G.B. Dogaru, E.M. Jianu, S. Riga, M. Tomoaia-Cotisel, A. Mocanu, L. Barbu-Tudoran, Gh. Tomoaia, "Osseointegration of biomimetic composite coating on titanium implants: in vivo study", Micromachines, 12(11), 1-24, (2021), https://doi.org/10.3390/mi12111352

2. R. Balint, I. Petean, P.T. Frangopol, A. Mocanu, G. Arghir, S. Riga, Gh. Tomoaia, O. Horovitz, M. Tomoaia-Cotisel, "Biomimetic nanocomposite structures designed for coating of orthopedic implants: AFM investigation", Studia UBB Chemia, 66(3), 141-160, (2021).

3. A. Mocanu, P.T. Frangopol, R. Balint, O. Cadar, I.M. Vancea, R. Mintau, O. Horovitz, M. Tomoaia-Cotisel, "Higuchi model applied to ions release from hydroxyapatites", Studia UBB Chemia, 66(3), 195-207, (2021).

4. D. Oltean-Dan, P.T. Frangopol, R. Balint, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel, "Biocompatibility of titanium implants coated with biocomposite in a rat model of femoral fracture", Studia UBB Chemia, 66(3) 73-87, (2021).

• Research original articles (BDI)

1. R. Balint, G.A. Paltinean, Gh. Tomoaia, D. Oltean-Dan, A. Mocanu, M. Tomoaia–Cotisel, "Biomaterials with enhanced biological functions for medical applications", Academy of Romanian Scientists, Annals Series on Biological Sciences, 10(1), 90-145 (2021).

2. C.R. Popa, Gh. Tomoaia, G.A. Paltinean, A. Mocanu, I. Cojocaru, M. Tomoaia-Cotisel, "Atmospheric pollution and the impact on the respiratory tract and lungs", Academy of Romanian Scientists, Annals Series on Biological Sciences, 10(1), 60-89 (2021).


• Communications at conferences

1. A. Avram, M. Gorea, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel, "Forsterite nanopowder for medical applications", Conferinţa Ştiinţifică de Primăvară a AOSR, 2021, Bucureşti, 10-11 iunie 2021, Volum de rezumate, pag. 65, online, oral presentation.

2. R. Balint, Gh. Tomoaia, D. Oltean-Dan, A. Mocanu, M. Tomoaia-Cotisel, "Nanomaterials with enhanced biological function for bone regeneration", Conferinţa Ştiinţifică de Primăvară a AOSR, 2021, Bucureşti, 10-11 iunie 2021, Volum de rezumate, pag. 66, online, oral presentation.

3. C.R. Popa, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel, "Atmospheric pollution and its effects on lungs", Conferinţa Ştiinţifică de Primăvară a AOSR, 2021, Bucureşti, 10-11 iunie 2021, Secţiunea Micro/Nano Biologie, Mediu, Volum de rezumate, pag. 69-70, online, oral presentation.

4. A. Avram, M. Gorea, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel, "Bioceramics based on magnesium silicate for bone regenerative medicine", International Scientific Conference, Applications of Chemistry in Nanosciences and Biomaterials Engineering, Bucharest, 25-26 June 2021, online, oral presentation.

5. R. Balint, Gh. Tomoaia, D. Oltean-Dan, A. Mocanu, M. Tomoaia-Cotisel, "Biomaterials based on multifunctional hydroxyapatite for orthopedic applications", International Scientific Conference, Applications of Chemistry in Nanosciences and Biomaterials Engineering, Bucharest, 25-26 June 2021, online, oral presentation.

6. C.R. Popa, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel, "Air pollution and its effects on Sars-Cov-2 variants", International Scientific Conference, Applications of Chemistry in Nanosciences and Biomaterials Engineering, Bucharest, 25-26 June 2021, online, oral presentation.

7. A. Avram, M. Gorea, A. Mocanu, M. Tomoaia-Cotisel, "Tailoring in Materials Engineering: The Influence of Synthesis Methods and Preparation Conditions on Forsterite (Mg2SiO4) Biomedical Applications", International Conference, NanoBio Mat 2021, - Applications of Chemistry in Nanosciences and Biomaterials Engineering for young researchers, 25-27 November, 2021, Bucharest, online, oral presentation.

8. R. Balint, A. Mocanu, M. Tomoaia-Cotisel, "Preparation and Characterization of Nanohydroxyapatites Doped with Various Biological Active Compounds with Biomedical Applications", International Conference, NanoBio Mat 2021, - Applications of Chemistry in Nanosciences and Biomaterials Engineering for young researchers, 25-27 November, 2021, Bucharest, online, oral presentation.

9. Gh. Tomoaia, R. Balint, M. Tomoaia-Cotisel, S. Riga, "Trans-disciplinaritate: designul structurilor nano-compozite bio-mimetice pentru implanturile medicale ortopedice", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia de medicină, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 36, online, prezentare orala.

10. Gh. Tomoaia, D. Oltean-Dan, A. Mocanu, M. Tomoaia-Cotisel, "Osteointegrarea implanturilor de titan acoperite cu biomateriale pe bază de hidroxiapatită multisubstituită şi stronţiu", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia de medicină, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 38, online, prezentare orala.

11. A. Avram, A. Mocanu, Gh. Tomoaia, S. Riga, M. Tomoaia-Cotisel, "Efectul antibacterian in vitro al nanopulberii de forsterit", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia de medicină, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 37, online, prezentare orala.

12. C.R. Popa, S. Riga, Gh.Tomoaia, A.Mocanu, M.Tomoaia-Cotisel, "Poluarea aerului în asociere cu COVID 19 în România", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia de medicină, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 39, online, prezentare orala.

13. S. Riga, Gh. Tomoaia, D. Oltean-Dan, A. Mocanu, M. Tomoaia-Cotisel, "Acoperiri biomimetice compozite pentru activarea suprafeţelor implantului de titan: abordare metodologică şi osteointegrare îmbunătăţită in vivo",Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia de medicină, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 38, online, prezentare orala.

14. D.A. Florea, C.T. Dobrota, S. Riga, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel, "Nanomateriale avansate: tehnologie inovatoare utilizată în cercetarea stomatologică”, Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia de medicină, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 39-40, online, prezentare orala.

15. R. Balint, A. Mocanu, Gh. Tomoaia, S. Riga, M. Tomoaia-Cotisel, "Biocompatibilitatea şi evaluarea in vivo a implanturilor de titan acoperite cu biocompozit", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia de medicină, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 42, online, prezentare orala.

16. C.R. Popa, S. Riga, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel, "Poluarea aerului în asociere cu COVID 19 asupra sistemului imunitar", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia ştiinţe biologice, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 18-19, online, prezentare orala.

17. L. Racz, A. Mocanu, Cs.-P. Racz, I. Kacso, O. Horovitz, M. Tomoaia-Cotisel, "Sistem de dispersie solidă de curcumină-proteine din zer cu solubilitate îmbunătăţită şi efect inhibitor al celulelor canceroase", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia ştiinţe biologice, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 22, online, prezentare orala.

18. R. Balint, Gh. Tomoaia, S. Riga, A. Mocanu, M. Tomoaia-Cotisel, "Scafolduri din compozite biomimetice cu hidroxiapatită multisubstituită şi colagen pentru aplicaţii biomedicale", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia ştiinţe biologice, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 24, online, prezentare orala.

19. A. Avram, A. Mocanu, Gh. Tomoaia, S. Riga, M. Tomoaia-Cotisel, "Efectul condiţiilor de sinteză asupra bioactivităţii nanoparticulelor de Mg2SiO4", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia ştiinţe biologice, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 24-25, online, prezentare orala.

20. D.A. Florea, C.T. Dobrota, R. Carpa, A. Mocanu, M. Tomoaia-Cotisel, "Tendinţe în tehnologiile de îngrijire orală", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia ştiinţe biologice, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 25-26, online, prezentare orala.

21. G.A. Paltinean, S. Riga, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel, "Compuşi bioactivi din plante utilizaţi ca agenţi terapeutici în aplicaţii biomedicale", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia ştiinţe biologice, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 25-26, online, prezentare orala.

22. L. Racz, Cs.-P. Racz , A. Mocanu, I. Kacso, M. Tomoaia-Cotisel, "Potenţialul terapeutic al curcuminei şi tehnici de a îmbunătăţi solubilitatea şi bioactivitatea in vivo", Conferinţa ştiinţifică naţională de toamnă - Tradiţii şi progrese în ştiinţa românească, 18-20 Noiembrie 2021, Secţia ştiinţe biologice, AOSR, 2021, Bucureşti, Volum de rezumate, pag. 30-31, online, prezentare orala.


• Romanian patent, OSIM

M. Tomoaia-Cotisel, A. Mocanu, A. Pop, C.L.Garbo, M.G. Bud, Gh. Tomoaia, C. Roman, O. Cadar, Cs.-P. Racz, "Nanomaterials based on multisubstituted hydroxyapatite and their fabrication procedure",Romanian Patent, OSIM, Bucharest, Romania, nr. 133124; BOPI, nr. 8, 2021, p.74.

• PhD-Thesis

Reka Balint, "Preparation and characterization of nanohydroxyapatites doped with various biological active compounds with biomedical applications", Babeş-Bolyai University, Cluj-Napoca, Romania, 29 September, pp.170 (2021), Scientific leader: Prof. Maria Tomoaia-Cotisel.

·   Phase 2 Dissemination:

• Research original articles (ISI)

1. A.Avram, S.Rapuntean, M.Gorea, Gh.Tomoaia, A.Mocanu, O.Horovitz, Gh.Rapuntean, M. Tomoaia-Cotisel, ”In vitro antibacterial efect of forsterite nanopowder: synthesis and characterization”, Environ. Sci. Pollut. Res., (2022) 29:77097–77112. https://doi.org/10.1007/s11356-022-21280-0

2. C.G. Floare, M. Bogdan, M. Tomoaia-Cotisel, A. Mocanu, „1H NMR spectroscopic characterization of inclusion complex of desferrioxamine B chelator and β-cyclodextrin”, J. Mol. Struct., 1248, 131477 (2022).

3. L. Z. Rácz, G.-A. Paltinean, I. Petean, Gh. Tomoaia, L. C. Pop, G. Arghir, E. Levei, A. Mocanu, Cs.-P. Rácz, M. Tomoaia-Cotisel, „Curcumin and Whey Protein Binding And Structural Characteristics of Their Complex Evidenced by Atomic Force Microscopy”, Stud. Univ. Babes-Bolyai, Chem., 67(3), 61-74 (2022).

4. L. Z. Rácz, Cs.-P. Rácz, O. Horovitz, Gh. Tomoaia, A. Mocanu, I. Kacso, M. Sárközi, M. Dan, S. Porav, G. Borodi, M. Tomoaia-Cotisel, ”Complexation of Curcumin using Whey Proteins to Enhance Aqueous Solubility, Stability and Antioxidant Property”, Stud. Univ. Babes-Bolyai, Chem., 67(3), 75-99 (2022).

5. L. Z. Rácz, Cs. P. Rácz, L. C. Pop, Gh. Tomoaia, A. Mocanu, I. Barbu, M. Sárközi, I. Roman, A. Avram, M. Tomoaia-Cotisel, V.-A. Toma, „Strategies for improving bioavailability, bioactivity, and physical-chemical behavior of the curcumin”, Molecules, 27, 6854 (2022).

• Research original articles (BDI)

1. R. Balint, G.A. Paltinean, D.A. Florea, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel, „Biomimetic and antibacterial composite for orthopedic implants”, Academy of Romanian Scientists Annals Series on Biological Sciences, 11(1), 120-145 (2022).

2. G.A. Paltinean, Gh. Tomoaia, S. Riga, A. Mocanu, M. Tomoaia-Cotisel, „Sylimarin based complexes – a mini review”, Academy of Romanian Scientists Annals Series on Biological Sciences, 11 (1), 146-166 (2022).

3. A. Avram, A.Mocanu, Gh.Tomoaia, M.Tomoaia-Cotisel, „Review on the biocompatibility and bioactivity of forsterite:in vitro and in vivo studies”, Academy of Romanian Scientists Annals Series on Biological Sciences, 11 (1), 167-190 (2022).


• Communications at conferences

1. A. Avram, A. Mocanu, Gh. Tomoaia, T. Mocan, M. Tomoaia-Cotisel, “Hydroxyapatite as a carrier for an efficient delivery of D3 and K2 vitamins”, Conferinţa Ştiinţifică Naţională de Primăvară „Era digitală – Provocări și Oportunităţi pentru Societatea Contemporană”, 6–7 May 2022, Biology Section, on-line, Book of Abstracts, p.101-102 (2022).

2. L. Racz, Cs. P. Racz, O. Horovitz, A. Mocanu, M. Tomoaia-Cotisel, “Insights into curcumin and whey protein interactions: Thermodynamic approach of curcumin - protein binding and potential biological effects”, Conferinţa Ştiinţifică Naţională de Primăvară „Era digitală – Provocări și Oportunităţi pentru Societatea Contemporană”, 6–7 May 2022, Biology Section, on-line, Book of Abstracts, p.103-104 (2022).

3. R. Balint, G.-A. Paltinean, D.-A. Florea, Gh. Tomoaia, D. Oltean-Dan, S. Riga, A. Mocanu, M. Tomoaia-Cotisel, „Biomimetic and antibacterial composite for orthopedic implants”, Conferința Științifică Națională de Primăvară „Era digitală – Provocări și Oportunități pentru Societatea Contemporană”, 6 – 7 May 2022, Medical Section, on-line, Book of Abstracts, p. 120-121 (2022).

4. C. T. Dobrota, D. A. Florea, R. Carpa, Gh. Tomoaia, A. Mocanu, M. Tomoaia-Cotisel, „Therapeutic Formulations containing plant secondary metabolites used to increase the efficiency of antibiotics”, Virtual International Scientific Conference on “Applications of Chemistry in Nanosciences and Biomaterials Engineering” NanoBioMat 2022 – Summer Edition, 22-24 June 2022, Session II, Natural Bioactive Compounds, on - line (2022).

5. G.-A. Paltinean, S. Rapuntean, Gh. Tomoaia, S. Riga, A. Mocanu, M. Tomoaia-Cotisel, „Antibacterial ability of polylactic acid microspheres loaded with hydroxyapatite and vancomycin”, Virtual International Scientific Conference on “Applications of Chemistry in Nanosciences and Biomaterials Engineering” NanoBioMat 2022 – Summer Edition, 22-24 June 2022. Oral presentation on Session V, Drug Delivery Applications of Nanomaterials and Biomaterials, on- line (2022). (Best Oral Presentation Prize).

6. L.Z. Racz, A. Avram, Gh. Tomoaia, L.-C. Pop, A. Kun, E. Forizs, V-M. Coman, C.-P Racz, A. Mocanu, M. Tomoaia-Cotisel, “Synthesis and characterization of compounds based on polyethylene glycol, curcumin and whey protein”, Fall National Scientific Conference Academy of Romanian Scientists – „The Role of Science in Solving Contemporary Crises”, 3–5 November 2022, Biology Section, Book of Abstracts, p. 72 (2022).

7. A. Avram, O. Soritau, Gh, Tomoaia, S. Riga, A. Mocanu, O. Horovitz, M. Tomoaia-Cotisel, “Gold nanoparticles: an advanced nanomaterial for medical and biological applications”, Conferința Științifică Națională de Toamna „Rolul științei în soluționarea crizelor contemporane”, Academia Oamenilor de stiinta, 3–5 November 2022, Fall National Scientific Conference Academy of Romanian Scientists – „The Role of Science in Solving Contemporary Crises”, 3–5 November 2022, Medical Science Section, Book of Abstracts, p. 99 (2022).

8. G.A. Paltinean, A. Mocanu, R. Balint, Gh. Tomoaia, Gh. Borodi, S. Riga, O. Horovitz, M. Tomoaia-Cotisel, “Bioactive multi-substituted hydroxyapatite and silver nanoparticles functionalized with vancomycin for antimicrobial applications”, Fall National Scientific Conference Academy of Romanian Scientists – „The Role of Science in Solving Contemporary Crises” , 3–5 November 2022, Medical Science Section, Book of Abstracts, p. 103 (2022).

9. O. Soritau, Gh. Tomoaia, A. Mocanu, O. Horovitz, C.-P. Racz, M. Tomoaia-Cotisel “The effect of multifunctional gold nanoparticles on cervical carcinoma cells, an evaluation study.”, Fall National Scientific Conference Academy of Romanian Scientists – „The Role of Science in Solving Contemporary Crises” , 3–5 November 2022, Medical Science Section, Book of Abstracts, p. 100 (2022).

10. T. Mocan, A. Mocanu, O. Cadar, C. Roman, A. Avram, M. Tomoaia-Cotisel, “In vitro testing of material prototypes with hydroxyapatite, vitamin D3, and vitamin K2 content.”, Fall National Scientific Conference Academy of Romanian Scientists – „The Role of Science in Solving Contemporary Crises” , 3–5 November 2022, Medical Science Section, Book of Abstracts, p. 102 (2022).

11. A. Avram, T. Mocan, A. Mocanu, Gh. Tomoaia, S. Riga, M. Tomoaia-Cotisel, „Promoting effect of nano hydroxyapatites and vitamin D3 on the osteogenic differentiation of osteoblasts and bone regeneration”, Virtual International Scientific Conference on “Applications of Chemistry in Nanosciences and Biomaterials Engineering” NanoBioMat 2022 – Winter Edition, Oral presentation, 24–26 November 2022.


• Seminars/Workshops

Workshop INA-MAT, organized at Fall National Scientific Conference Academy of Romanian Scientists – „The Role of Science in Solving Contemporary Crises” , Cluj-Napoca, 3–5 November, 2022.

1. O. Soritau, Gh. Tomoaia, A. Mocanu, O. Horovitz, C.-P. Racz, M. Tomoaia-Cotisel, “The effect of multifunctional gold nanoparticles on cervical carcinoma cells. an evaluation study.”, Oral presentation, Book of Abstracts, ISSN 2601-5102, vol. 16 (2), p. 100 (2022).

2. A. Avram, O. Soritau, Gh, Tomoaia, S. Riga, A. Mocanu, O. Horovitz, M. Tomoaia-Cotisel, “Gold nanoparticles: an advanced nanomaterial for medical and biological applications”, Oral presentation, Book of Abstracts, ISSN 2601-5102, vol. 16 (2), p.99 (2022).

3. G.A. Paltinean, A. Mocanu, R. Balint, Gh. Tomoaia, Gh. Borodi, S. Riga, O. Horovitz, M. Tomoaia-Cotisel, “Bioactive multi-substituted hydroxyapatite and silver nanoparticles functionalized with vancomycin for antimicrobial applications”, Oral presentation, Book of Abstracts, ISSN 2601-5102, vol. 16 (2), p. 103 (2022).

4. R. Balint, D. Oltean-Dan, Gh. Tomoaia, A. Jecan, H.-R.-C. Benea, Gh. Borodi, A. Mocanu, O. Horovitz, M. Tomoaia-Cotisel, “Biomimetic compozites for titanium implants”, Prezentare orala, Book of Abstracts, ISSN 2601-5102, vol. 16 (2), p.101(2022).


• PhD-Thesis

Levente-Zsolt Racz, “The physico-chemical study of some natural compounds with biological activity”, Babes-Bolyai University, 28 September, (2022), pp. 335. Scientific advisor, Univ. Prof. Dr. Maria Tomoaia-Cotisel.

·   Phase 3 Dissemination:

• Research original articles (ISI)

1. C.-P. Racz, L.Z. Racz, C.G. Floare, Gh. Tomoaia, O. Horovitz, S. Riga, I. Kacso, Gh. Borodi, M. Sarkozi, A. Mocanu, C. Roman, M. Tomoaia-Cotisel, „Curcumin and whey protein concentrate binding: Thermodynamic and structural approach”, , Food. Hydrocoll., 139, 1088547 (2023).

2. A. Zastulka, S. Clichici, M. Tomoaia-Cotisel, A. Mocanu, C. Roman, C.-D. Olteanu, B. Culic, T. Mocan, “Recent Trends in Hydroxyapatite Supplementation for Osteoregenerative Purposes”, J. Materials., 116 (3), 1303 (2023).

3. A.-D. Florea, L. C. Pop, H.-R.-C. Benea, Gh. Tomoaia, C.-P. Racz, A. Mocanu, C.-T. Dobrota, R. Balint, O. Soritau, M. Tomoaia-Cotisel, “Remineralization induced by biomimetic hydroxyapatite toothpastes on human enamel”, Biomimetics., 8 (6), 450, (2023).

4.A.-D. Florea, C. T. Dobrota, R. Carpa, C.-P. Racz, Gh. Tomoaia, A. Mocanu, A. Avram, O. Soritau, L.C. Pop, M. Tomoaia-Cotisel, Optimization of Functional Toothpaste Formulation Containing Nano-hydroxyapatite and Birch Extract for Daily Oral Care, Materials, 616 (22), 7143 (2023).

5. A. Mocanu, D. A. Florea, Gh. Tomoaia, L.-C. Pop, A. Danistean, S. Rapuntean, O. Horovitz, M. Tomoaia-Cotisel, “Nanocomposite based on hydroxyapatite and silver with antibacterial activity”, Stud. Univ. Babes-Bolyai Chem., 68 (3), 7-18, ( 2023).

6. A. Avram, D. Florea, F. Goga, M. Gorea, A. Mocanu, Gh. Tomoaia, I. Petean, A.-Z. Kun, O. Horovitz, M. Tomoaia-Cotisel,” Mechanisms in the synthesis of forsterite nanoparticles based on thermodynamic approach”, Stud. Univ. Babes-Bolyai, Chem., 68 (2), 37-51 (2023).

7. A.-D. Florea, A. Mocanu, L.C. Pop, Gh. Tomoaia, C.-T. Dobrota, Cs. Varheli Jr., M. Tomoaia-Cotisel, “Remineralization of tooth enamel with hydroxyapatite nanoparticles: an in vitro study”, Stud. Univ. Babes-Bolyai, Chem., ,68 (2), 99-113 (2023).

• Research original articles (BDI)

8. A. Avram, A. Mocanu, Gh. Tomoaia, C.L. Rosoiu, C.T. Dobrota, D.A. Florea, M. Tomoaia-Cotisel, “Unveiling the Complexity of Red Blood Cells: Insights into Structure, Properties and Functions”, Academy of Romanian Scientists Annals Series on Biological Sciences, 12(1), 129-154 (2023)

9. A. Avram, A. Mocanu, S. Riga, M. Tomoaia-Cotisel, Relationship between dentifrices based on hydroxyapatites and human enamel remineralization, Rom. Biotechnol. Lett., 28 (2), 3908-3920 (2023).

• Communications at conferences

1. D.A Florea, C.T. Dobrota, Gh. Tomoaia, A. Avram, A. Mocanu, A. Mocanu, O. Horovitz, T. Mocan, M. Tomoaia-Cotisel, “The Interfacial Bonding of Hidroxyapatite Prisms and Protein Units on Human Teeth Enamel, Explored by AFM”, , Oral presentation, Romanian Academy of Scientists, National Spring Scientific Conference,“Digital transformation in the sciences”, 19-20 May 2023, Biology Section, on-line, Book of Abstracts, p. 107-108 (2023).

2.D.A. Florea, Gh. Tomoaia, C.T. Dobrota, A. Mocanu, A. Avram, O. Horovitz, O. Soritau, M. Tomoaia-Cotisel, “Remineralization of Human Teeth Enamel with Toothpastes Comprising Hydroxyapatites and Antimicrobial Natural Agents”, Oral presentation, Romanian Academy of Scientists, National Spring Scientific Conference,“Digital transformation in the sciences”, 19-20 May 2023, Biology Section, on-line, Book of Abstracts, p. 108-109 (2023).

3. D.A. Florea, Gh. Tomoaia, C.T. Dobrota, L.C. Pop, A. Mocanu, O. Horovitz, T. Mocan, A. Avram, M. Tomoaia-Cotisel, “Ceramic Restoration for Human Teeth Enamel”, Oral presentation, Romanian Academy of Scientists, National Spring Scientific Conference,“Digital transformation in the sciences”, 19-20 May 2023, Biology Section, on-line, Book of Abstracts, p. 109-111 (2023).

4. D. Oltean-Dan, Gh. Tomoaia, A. Avram, A. Mocanu, M. Tomoaia-Cotisel, “Research and development of biomimetic strontium substituted coating nanomaterials to enhance the titanium implants osseointegration”, Oral presentation, Romanian Academy of Scientists, National Spring Scientific Conference,“Digital transformation in the sciences”, 19-20 May 2023, Biology Section, on-line, Book of Abstracts, p. 111-112 (2023).

5. D.A. Florea, C.T. Dobrota, C.L. Rosoiu, Gh. Tomoaia, A. Avram, A. Mocanu, M. Tomoaia-Cotisel, “The antibacterial properties of toothpaste formulations comprising hydroxyapatite and birch extract”, Oral presentation, Romanian Academy of Scientists, Conferința Științifică Națională de Toamnă “Science for a Healthy Society”, 21-23 septembrie 2023, Medical Section, on-line, Book of Abstracts, p. 106-107 (2023).

6. D.A. Florea, Gh. Tomoaia, S. Riga, H.-R.-C. Benea, A. Avram, C.T. Dobrota, T. Mocan, A. Mocanu, M. Tomoaia-Cotisel, “Human enamel remineralization efficiency of various toothpastes based on biomimetic hydroxyapatites”, Oral presentation, Romanian Academy of Scientists, National Autumn Scientific Conference“ Science for a Healthy Society”, 21-23 September 2023 Book of Abstracts, p. 107-108 (2023).

7.A. Florea, C.T. Dobrota, A. Avram, Gh. Tomoaia, H.-R.-C. Benea, C.L. Rosoiu, A. Mocanu, M. Tomoaia-Cotisel,“The effect of nano-hydroxyapatites on in vitro remineralization of human teeth enamel lesions”, Oral presentation, Romanian Academy of Scientists, National Autumn Scientific Conference“ Science for a Healthy Society”, 21-23 September 2023 Book of Abstracts, p. 108-109 (2023).

8. C.G. Floare, C.-P. Racz, A. Avram, Gh. Tomoaia, S. Riga, T. Mocan, G. Borodi, A. mocanu, M. Tomoaia-Cotisel, “Noncovalent Interactions of Curcumin and Whey Protein: The Effect on Curcumin Stability and Its Biological Function for Human Health Benefits”, Oral presentation , Romanian Academy of Scientists, National Autumn Scientific Conference“ Science for a Healthy Society”, 21-23 September 2023, Biology Section, on-line, Book of Abstracts, p. 109-110 (2023).

9. C. P. Racz, L. Z. Racz, C. G. Floare, Gh. Tomoaia, O. Horovitz, S. Riga, I. Kacso, G. Borodi, M. Sarkozi, A. Mocanu, C. Roman and M. Tomoaia-Cotisel, “Curcumin and whey protein concentrate binding: Molecular docking investigation”, (T8-P), Oral presentation and Poster presentation: 15th International Conference on Physics of Advanced Materials and 6th Autumn School on Physics of Advanced Materials, ICPAM-15 and PAMS-6, 19-26 November, (2023), Sharm El Sheikh, Egypt.


• PhD-Thesis

Alexandra-Diana Florea(married:Dobrota),“Advanced biomaterials based on multisubstituted hydroxyapatite with medical applications”, Babes-Bolyai University, Cluj-Napoca, 28 September, 2023, pp. 229. Scientific advisor, Univ. Prof. Dr. Maria Tomoaia-Cotisel.


• Diploma of excelence

Maria Tomoaia-Cotisel, Aurora Mocanu, Alexandru Pop, Corina Lacramioara Garbo, Marius Gheorghe Bud, Gheorghe Tomoaia, Cecilia Roman, Oana Cadar, Csaba - Pal Racz, “Nanomateriale pe baza de Hidroxiapatita multisubstituita si pocedeu de obtinere a acestora”, Diploma of Excellence at The 21st “PRO-INVENT” International Exhibition of Research, Innovation and Inventions, Cluj-Napoca, 25-27 October, 2023.