Scientific papers

 
  1. Engineered Biocatalysts for the Asymmetric Synthesis of D-Phenylalanines

    Tomoiagă Raluca Bianca, Nagy Levente Csaba, Boros Krisztina, Moisă Mădălina Elena, Bencze László Csaba
    ACS Catalysis (2025) 15(9): 7361–7389
    DOI: 10.1021/acscatal.5c00837

  2. Fine tuning enzyme activity assays for monitoring the enzymatic hydrolysis of PET

    Boros Krisztina, Nagy Blanka Eszter, Tomoiagă Raluca Bianca, Tőtős Róbert, Toșa Monica Ioana, Paizs Csaba, Bencze László Csaba
    Scientific Reports (2025) 15(1): 7361–7389
    DOI: 10.1038/s41598-024-84177-7

  3. The Biocatalytic Potential of Aromatic Ammonia–Lyase from Loktanella atrilutea

    Tomoiaga R.B., Ágoston G., Boros K., Nagy L.C., Toşa M.I., Paizs C., Bencze L.C.
    ChemBioChem (2024) 25(9): e202400011
    DOI: 10.1002/cbic.202400011

  4. Immobilization of D-amino acid dehydrogenase from Ureibacillus thermosphaericus

    Boros K., Gal L., Gal C.A., Wäscher M., Tomoiagă R.B., Toşa M.I., Pietruszka J., Bencze L.C.
    Process Biochemistry (2024) 140: 45-55
    DOI: 10.1016/j.procbio.2024.02.014

  5. Ancestral L-amino acid oxidase: From substrate scope exploration to phenylalanine ammonia-lyase assay

    Tomoiagă R.B., Ursu M., Boros K., Nagy L.C., Bencze L.C.
    Journal of Biotechnology (2023) 377(4): 43-52
    DOI: 10.1016/j.jbiotec.2023.10.006

  6. Phenylalanine ammonia-lyases: combining protein engineering and natural diversity

    Tomoiagă R.B., Tork S.D., Filip A., Nagy L.C., Bencze L.C.
    Applied Microbiology and Biotechnology (2023) 107(4): 1243-1256
    DOI: 10.1007/s00253-023-12374-x

  7. Engineered, Scalable Production of Optically Pure l-Phenylalanines Using Phenylalanine Ammonia-Lyase from Arabidopsis thaliana

    Tork S.D., Nagy E.Z.A., Tomoiagă R.B., Bencze L.C.
    Journal of Organic Chemistry (2023) 88(2): 852-862
    DOI: 10.1021/acs.joc.2c02106

  8. A robust and efficient lipase based nanobiocatalyst for phenothiazinyl-ethanol resolution

    Spelmezan C.-G., Katona G., Bencze L.C., Paizs C., Toşa M.I.
    Reaction Chemistry and Engineering (2023) 88: 852-862
    DOI: 10.1039/d2re00515h

  9. How to identify and characterize novel transaminases? Two novel transaminases with opposite enantioselectivity for the synthesis of optically active amines

    Gal C.A., Barabás L.-E., Varga A., Csuka P., Bencze L.C., Toşa M.I., Poppe L., Paizs C.
    Molecular Catalysis (2022) 531(11): 112660
    DOI: 10.1016/j.mcat.2022.112660

  10. Towards a general approach for tailoring the hydrophobic binding site of phenylalanine ammonia-lyases

    Tork S.D., Moisă M.E., Cserepes L., Filip A., Nagy L.C., Irimie F.D., Bencze L.C.
    Scientific Reports (2022) 12(1): 10606
    DOI: 10.1038/s41598-022-14585-0

  11. Toolbox for the structure-guided evolution of ferulic acid decarboxylase (FDC)

    Duță H., Filip A., Nagy L.C., Nagy E.Z.A., Tőtős R., Bencze L.C.
    Scientific Reports (2022) 12(1): 3347
    DOI: 10.1038/s41598-022-07110-w

  12. Deep eutectic solvents-a new additive in the encapsulation of lipase B from: Candida antarctica: Biocatalytic applications

    Dudu A.I., Bencze L.C., Paizs C., Toşa M.I.
    Reaction Chemistry and Engineering (2022) 7(2): 442-449
    DOI: 10.1039/d1re00469g

  13. PRODUCTION OF RECOMBINANT, NON-TAGGED PHENYLALANINE AMMONIA-LYASES EMPLOYING TEV PROTEASE-REMOVABLE AFFINITY TAGS

    Filip A., Bata Z., Anghel A.E., Poppe L., Bencze L.C.
    Studia Universitatis Babes-Bolyai Chemia (2022) 67(4): 27-46
    DOI: 10.24193/subbchem.2022.4.03

  14. Lipase on carbon nanotubes-an active, selective, stable and easy-to-optimize nanobiocatalyst for kinetic resolutions

    Gal C.A., Barabás L.E., Bartha-Vári J.-H., Moisă M.E., Balogh-Weiser D., Bencze L.C., Poppe L., Paizs C., Toşa M.I.
    Reaction Chemistry and Engineering (2021) 6(12): 2391-2399
    DOI: 10.1039/d1re00342a

  15. Robust, site-specifically immobilized phenylalanine ammonia-lyases for the enantioselective ammonia addition of cinnamic acids

    Boros K., Moisă M.E., Nagy C.L., Paizs C., Toşa M.I., Bencze L.C.
    Catalysis Science and Technology (2021) 11(16): 5553-5563
    DOI: 10.1039/d1cy00195g

  16. Green Process for the Enzymatic Synthesis of Aroma Compounds Mediated by Lipases Entrapped in Tailored Sol-Gel Matrices

    Dudu A.I., Lacatus M.A., Bencze L.C., Paizs C., Toşa M.I.
    ACS Sustainable Chemistry and Engineering (2021) 9(15): 5461-5469
    DOI: 10.1021/acssuschemeng.1c00965

  17. A novel phenylalanine ammonia-lyase from Pseudozyma antarctica for stereoselective biotransformations of unnatural amino acids

    Varga A., Csuka P., Sonesouphap O., Bánóczi G., Toşa M.I., Katona G., Molnár Z., Bencze L.C., Poppe L., Paizs C.
    Catalysis Today (2021) 366(8): 185-194
    DOI: 10.1016/j.cattod.2020.04.002

  18. Protein level alteration of endocannabinoid system components after chronic, oral self-administration of three atypical antipsychotics in rat

    Bába L.-I., Kolcsár M., Gáll Z., Bencze L.C., Man A., Kun I.Z.
    Acta Marisiensis - Seria Medica (2021) 67(1): 60-66
    DOI: 10.2478/amma-2021-0008

  19. Solvent-Free Biocatalytic Synthesis of 2,5-bis-(Hydroxymethyl)Furan Fatty Acid Diesters from Renewable Resources

    Lăcătuş M.A., Dudu A.I., Bencze L.C., Katona G., Irimie F.-D., Paizs C., Toşa M.I.
    ACS Sustainable Chemistry and Engineering (2020) 8(3): 1611-1617
    DOI: 10.1021/acssuschemeng.9b06442

  20. Fluorescent enzyme-coupled activity assay for phenylalanine ammonia-lyases

    Moisă M.E., Amariei D.A., Nagy E.Z.A., Szarvas N., Toşa M.I., Paizs C., Bencze L.C.
    Scientific Reports (2020) 10(1): 18418
    DOI: 10.1038/s41598-020-75474-y

  21. Saturation mutagenesis for phenylalanine ammonia lyases of enhanced catalytic properties

    Tomoiagă R.B., Tork S.D., Horváth I., Filip A., Nagy L.C., Bencze L.C.
    Biomolecules (2020) 10(6): 838
    DOI: 10.3390/biom10060838

  22. Efficient biodiesel production catalyzed by nanobioconjugate of lipase from pseudomonas fluorescens

    Bartha-Vári J.-H., Moisă M.E., Bencze L.C., Irimie F.-D., Paizs C., Toşa M.I.
    Molecules (2020) 25(3): 651
    DOI: 10.3390/molecules25030651

  23. Effcient and stable magnetic chitosan-lipase B from candida antarctica bioconjugates in the enzymatic kinetic resolution of racemic heteroarylethanols

    Spelmezan C.G., Bencze L.C., Katona G., Irimie F.D., Paizs C., Toşa M.I.
    Molecules (2020) 25(2): 350
    DOI: 10.3390/molecules25020350

  24. Mapping the Hydrophobic Substrate Binding Site of Phenylalanine Ammonia-Lyase from Petroselinum crispum

    Nagy E.Z.A., Tork S.D., Lang P.A., Filip A., Irimie F.D., Poppe L., Toşa M.I., Schofield C.J., Brem J., Paizs C., Bencze L.C.
    ACS Catalysis (2019) 9(9): 8825-8834
    DOI: 10.1021/acscatal.9b02108

  25. The production of L- and D-phenylalanines using engineered phenylalanine ammonia lyases from Petroselinum crispum

    Tork S.D., Nagy E.Z.A., Cserepes L., Bordea D.M., Nagy B., Toşa M.I., Paizs C., Bencze L.C.
    Scientific Reports (2019) 9(1): 20123
    DOI: 10.1038/s41598-019-56554-0

  26. Exploring the substrate scope of ferulic acid decarboxylase (FDC1) from Saccharomyces cerevisiae

    Nagy E.Z.A., Nagy C.L., Filip A., Nagy K., Gál E., Tőtős R., Poppe L., Paizs C., Bencze L.C.
    Scientific reports (2019) 9(1): 647
    DOI: 10.1038/s41598-018-36977-x

  27. Continuous-flow enzymatic kinetic resolution mediated by a lipase nanobioconjugate

    Moisă M.E., Bencze L.C., Paizs C., Toşa M.I.
    Studia Universitatis Babes-Bolyai Chemia (2019) 64(2Tom1): 79-86
    DOI: 10.24193/subbchem.2019.2.07

  28. Click reaction-aided enzymatic kinetic resolution of secondary alcohols

    Moisă M.E., Poppe L., Gal C.A., Bencze L.C., Irimie F.D., Paizs C., Peter F., Toşa M.I.
    Reaction Chemistry and Engineering (2018) 3(5): 790-798
    DOI: 10.1039/c8re00091c

  29. Tailored Mutants of Phenylalanine Ammonia-Lyase from Petroselinum crispum for the Synthesis of Bulky l- and d-Arylalanines

    Filip A., Nagy E.Z.A., Tork S.D., Bánóczi G., Toşa M.I., Irimie F.D., Poppe L., Paizs C., Bencze L.C.
    ChemCatChem (2018) 10(12): 2627-2633
    DOI: 10.1002/cctc.201800258

  30. Eco-Friendly Enzymatic Production of 2,5-Bis(hydroxymethyl)furan Fatty Acid Diesters, Potential Biodiesel Additives

    Lăcătuş M.A., Bencze L.C., Toşa M.I., Paizs C., Irimie F.-D.
    ACS Sustainable Chemistry and Engineering (2018) 6(9): 11353-11359
    DOI: 10.1021/acssuschemeng.8b01206

  31. Pseudomonas fluorescens Strain R124 Encodes Three Different MIO Enzymes

    Csuka P., Juhász V., Kohári S., Filip A., Varga A., Sátorhelyi P., Bencze L.C., Barton H., Paizs C., Poppe L.
    ChemBioChem (2018) 19(4): 411-418
    DOI: 10.1002/cbic.201700530

  32. A Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa

    Andolina G., Bencze L.-C., Zerbe K., Müller M., Steinmann J., Kocherla H., Mondal M., Sobek J., Moehle K., Malojčić G., Wollscheid B., Robinson J.A.
    ACS Chemical Biology (2018) 13(3): 666-675
    DOI: 10.1021/acschembio.7b00822

  33. Heterocycles 48. synthesis, characterization and biological evaluation of imidazo[2,1-b][1,3,4]thiadiazole derivatives as anti-inflammatory agents

    Cristina A., Leonte D., Vlase L., Bencze L.C., Imre S., Marc G., Apan B., Mogosan C., Zaharia V.
    Molecules (2018) 23(10): 2425
    DOI: 10.3390/molecules23102425

  34. Heterocycles 44. Synthesis, characterization and anticancer activity of new thiazole ortho-hydroxychalcones

    Coman F.-M., Mbaveng A.T., Leonte D., Bencze L.C., Vlase L., Imre S., Kuete V., Efferth T., Zaharia V.
    Medicinal Chemistry Research (2018) 27(5): 1396-1407
    DOI: 10.1007/s00044-018-2156-2

  35. Heterocycles 42. Synthesis and characterization of new thiazolo[3,2-b] [1,2,4]triazole derivatives with anti-inflammatory potential

    Cristina A., Leonte D., Vlase L., Bencze L.C., Imre S., Zaharia V.
    Farmacia (2018) 66(1): 88-96

  36. Heterocycles 43. Synthesis, characterization and antioxidant activity of some thiazole hydroxychalcones and their flavonoidic derivatives

    Constantinescu T., Leonte D., Bencze L.C., Vlase L., Imre S., Hanganu D., Zaharia V.
    Farmacia (2018) 66(4): 663-673
    DOI: 10.31925/farmacia.2018.4.16

  37. Heterocycles 46. Synthesis, characterization and biological evaluation of thiazolo[3,2-b][1,2,4]triazoles bearing benzenesulfonamide moiety

    Cristina A., Leonte D., Vlase L., Bencze L.C., Imre S., Apan B., Mogoșan C., Zaharia V.
    Farmacia (2018) 66(5): 883-893
    DOI: 10.31925/farmacia.2018.5.20

  38. Expanding the substrate scope of phenylalanine ammonia-lyase from: Petroselinum crispum towards styrylalanines

    Bencze L.C., Filip A., Bánóczi G., Toşa M.I., Irimie F.D., Gellért Á., Poppe L., Paizs C.
    Organic and Biomolecular Chemistry (2017) 15(17): 3717-3727
    DOI: 10.1039/c7ob00562h

  39. Tailored sol-gel immobilized lipase preparates for the enzymatic kinetic resolution of heteroaromatic alcohols in batch and continuous flow systems

    Moisă M.E., Spelmezan C.G., Paul C., Bartha-Vári J.H., Bencze L.C., Irimie F.D., Paizs C., Péter F., Toşa M.I.
    RSC Advances (2017) 7(83): 52977-52987
    DOI: 10.1039/c7ra10157k

  40. A Methylidene Group in the Phosphonic Acid Analogue of Phenylalanine Reverses the Enantiopreference of Binding to Phenylalanine Ammonia-Lyases

    Bata Z., Qian R., Roller A., Horak J., Bencze L.C., Paizs C., Hammerschmidt F., Vértessy B.G., Poppe L.
    Advanced Synthesis and Catalysis (2017) 359(12): 2109-2120
    DOI: 10.1002/adsc.201700428

  41. Covalently Immobilized Lipases are Efficient Stereoselective Catalysts for the Kinetic Resolution of rac-(5-Phenylfuran-2-yl)-β-alanine Ethyl Ester Hydrochlorides

    Nagy B., Galla Z., Bencze L.C., Toşa M.I., Paizs C., Forró E., Fülöp F.
    European Journal of Organic Chemistry (2017) 2017(20): 2878-2882
    DOI: 10.1002/ejoc.201700174

  42. Aminated single-walled carbon nanotubes as carrier for covalent immobilization of phenylalanine ammonia-lyase

    Bartha-Vári J.H., Bencze L.C., Bell E., Poppe L., Katona G., Irimie F.-D., Paizs C., Toşa M.I.
    Periodica Polytechnica Chemical Engineering (2017) 61(1): 59-66
    DOI: 10.3311/PPch.10417

  43. A novel phenylalanine ammonia-lyase from Kangiella koreensis

    Varga A., Bata Z., Csuka P., Bordea D.M., Vértessy B.G., Marcovici A., Irimie F.D., Poppe L., Bencze L.C.
    Studia Universitatis Babes-Bolyai Chemia (2017) 62(3): 293-308
    DOI: 10.24193/subbchem.2017.3.25

  44. Validated LC-MS/MS method for the concomitant determination of amoxicillin and clavulanic acid from human plasma

    Balázsi J., Paizs C., Irimie F.-D., Toşa M.I., Bencze L.C., Tőtős R.
    Studia Universitatis Babes-Bolyai Chemia (2017) 62(2Tom1): 167-178
    DOI: 10.24193/subbchem.2017.2.12

  45. Heterocycles 41. Synthesis and characterisation of new thiazole β-amino acids and β-amino esters

    Leonte D., Bencze L.C., Tőtős R., Zaharia V.
    Farmacia (2017) 65(2): 207-213
    DOI: 10.24193/subbchem.2017.2.17

  46. Nanobioconjugates of Candida antarctica lipase B and single-walled carbon nanotubes in biodiesel production

    Bencze L.C., Bartha-Vári J.H., Katona G., Toşa M.I., Paizs C., Irimie F.-D.
    Bioresource Technology (2016) 200: 853-860
    DOI: 10.1016/j.biortech.2015.10.072

  47. Influence of the aromatic moiety in α- And β-arylalanines on their biotransformation with phenylalanine 2,3-aminomutase from: Pantoea agglomerans

    Varga A., Bánóczi G., Nagy B., Bencze L.C., Toşa M.I., Gellért Á., Irimie F.D., Rétey J., Poppe L., Paizs C.
    RSC Advances (2016) 6(61): 56412-56420
    DOI: 10.1039/c6ra02964g

  48. Microfluidic multiple cell chip reactor filled with enzyme-coated magnetic nanoparticles - An efficient and flexible novel tool for enzyme catalyzed biotransformations

    Ender F., Weiser D., Nagy B., Bencze C.L., Paizs C., Pálovics P., Poppe L.
    Journal of Flow Chemistry (2016) 6(1): 43-52
    DOI: 10.1556/1846.2015.00036

  49. Heterocycles 36. Single-walled carbon nanotubes-bound n,n-diethyl ethanolamine as mild and efficient racemisation agent in the enzymatic DKR of 2-Arylthiazol-4-yl-alanines

    Leonte D., Bencze L.C., Paizs C., Toşa M.I., Zaharia V., Dan Irimie F.
    Molecules (2016) 21(1): 25
    DOI: 10.3390/molecules21010025

  50. Expression and purification of recombinant phenylalanine 2,3-aminomutase from Pantoea agglomerans

    Varga A., Filip A., Bencze L.-C., Sátorhelyi P., Bell E., Vértessy B.G., Poppe L., Paizs C.
    Studia Universitatis Babes-Bolyai Chemia (2016) 61(2): 7-19

  51. Expression and purification of recombinant phenylalanine ammonia-lyase from Petroselinum crispum

    Dima N.A., Filip A., Bencze L.C., Oláh M., Sátorhelyi P., Vértessy B.G., Poppe L., Paizs C.
    Studia Universitatis Babes-Bolyai Chemia (2016) 61(2): 21-34

  52. Phenylalanine Ammonia-Lyase-Catalyzed Deamination of an Acyclic Amino Acid: Enzyme Mechanistic Studies Aided by a Novel Microreactor Filled with Magnetic Nanoparticles

    Weiser D., Bencze L.C., Bánóczi G., Ender F., Kiss R., Kõkai E., Szilágyi A., Vértessy B.G., Farkas Ö., Paizs C., Poppe L.
    ChemBioChem (2015) 16(16): 2283-2288
    DOI: 10.1002/cbic.201500444

  53. Synthesis of enantiopure l-(5-phenylfuran-2-yl)alanines by a sequential multienzyme process

    Bencze L.C., Komjáti B., Pop L.-A., Paizs C., Irimie F.-D., Nagy J., Poppe L., Toşa M.I.
    Tetrahedron Asymmetry (2015) 26(18-19): 59353
    DOI: 10.1016/j.tetasy.2015.08.004

  54. Heterocycles 38. Biocatalytic synthesis of new heterocyclic mannich bases and derivatives

    Leonte D., Bencze L.C., Paizs C., Irimie F.D., Zaharia V.
    Molecules (2015) 20(7): 12300-12313
    DOI: 10.3390/molecules200712300

  55. Sequential enzymatic procedure for the preparation of enantiomerically pure 2-heteroaryl-2-hydroxyacetic acids

    Naghi M.A., Bencze L.C., Brem J., Paizs C., Irimie F.D., Toşa M.I.
    Tetrahedron Asymmetry (2012) 23(2): 181-187
    DOI: 10.1016/j.tetasy.2012.01.019

  56. Chemoenzymatic preparation of 1-heteroarylethanamines of low solubility

    Brem J., Bencze L.-C., Liljeblad A., Turcu M.C., Paizs C., Irimie F.-D., Kanerva L.T.
    European Journal of Organic Chemistry (2012) 11(17): 3288-3294
    DOI: 10.1002/ejoc.201200330

  57. Chemoenzymatic synthesis of highly enantiomerically enriched secondary alcohols with a thiazolic core

    Pop L., Lassalas P., Bencze L.C., Toşa M.I., Nagy B., Irimie F.D., Hoarau C.
    Tetrahedron Asymmetry (2012) 23(6-7): 474-481
    DOI: 10.1016/j.tetasy.2012.03.014

  58. Stereoselective bioreduction of 1-(5-phenylfuran-2-yl)-ethanones mediated by baker's yeast

    Trif M., Kall N.H., Naghi M.A., Bencze L.C.
    Biocatalysis and Biotransformation (2012) 30(2): 177-183
    DOI: 10.3109/10242422.2011.638374

  59. Chemoenzymatic one-pot synthesis of both (R)- and (S)-aryl-1,2-ethanediols

    Bencze L.C., Paizs C., Toşa M.I., Irimie F.D., Rétey J.
    ChemCatChem (2011) 3(2): 343-346
    DOI: 10.1002/cctc.201000295

  60. Sequential use of regio- and stereoselective lipases for the efficient kinetic resolution of racemic 1-(5-phenylfuran-2-yl)ethane-1,2-diols

    Bencze L.C., Paizs C., Toşa M.I., Irimie F.D.
    Tetrahedron Asymmetry (2011) 22(6): 675-683
    DOI: 10.1016/j.tetasy.2011.03.006

  61. CaL-B a highly selective biocatalyst for the kinetic resolution of furylbenzthiazole-2-yl-ethanols and acetates

    Bencze L.C., Paizs C., Toşa M.I., Trif M., Irimie F.D.
    Tetrahedron Asymmetry (2010) 21(16): 1999-2004
    DOI: 10.1016/j.tetasy.2010.06.010

  62. Synthesis of enantiomerically enriched (R)- and (S)-benzofuranyl- and benzo[b]thiophenyl-1,2-ethanediols via enantiopure cyanohydrins as intermediates

    Bencze L.C., Paizs C., Toşa M.I., Vass E., Irimie F.D.
    Tetrahedron Asymmetry (2010) 21(4): 443-450
    DOI: 10.1016/j.tetasy.2010.01.018

  63. Substituent effects on the stereochemical outcome of the baker's yeast-mediated biotransformation of α-hydroxy- and α-acetoxymethyl-5-phenylfuran-2-yl-ethanones

    Bencze L.C., Paizs C., Toşa M.I., Irimie F.D.
    Tetrahedron Asymmetry (2010) 21(3): 356-364
    DOI: 10.1016/j.tetasy.2010.02.004

  64. 2-amino-3-(5-phenylfuran-2-yl)propionic acids and 5-phenylfuran-2-ylacrylic acids are novel substrates of phenylalanine ammonia-lyase

    Paizs C., Toşa M.I., Bencze L.C., Brem J., Irimie F.D., Rétey J.
    Heterocycles (2010) 82(2): 1217-1228
    DOI: 10.3987/COM-10-S(E)60

  65. The effect of electromagnetic fields on baker's yeast population dynamics, biocatalytic activity and selectivity

    Sandu D., Lingvay I., Lányi S., Micu D.D., Popescu C.L., Brem J., Bencze L.C., Paizs C.
    Studia Universitatis Babes-Bolyai Chemia (2009) 4(2): 195-201