Applied Heterocyclic Organic and Organometallic Chemistry

Synthesis and structural characterization of N, O, S, P, As - containing heterocyclic systems. Synthetic strategies based on microwave and ultrasound activation developed as alternatives to the classical methods. For the labile compounds, the syntheses are conducted under controlled atmosphere (air- and moisture-free) using Schlenk lines. The new compounds obtained so far in our group were tested with very good results for:
- Biomedical applications (i.e.: antiproliferative, antimicrobial, antidepressant)
- Fluorescent materials (including two-photon emission)
- Organic Dyes
- Electrochemical biosensors
- Anticorrosive Materials
- Forensic chemistry

Team leader, Contact person: Prof.dr. Luminita Silaghi-Dumitrescu, Email: lusi@chem.ubbcluj.ro

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The chemistry of low coordinated p-block elements

The research activities conducted in our group aim for the synthesis and characterization of some element-organic derivatives containing low coordinated p-block elements (such as heavy heteroallenes, metalylenes, etc). The compounds are synthesized under controlled atmosphere, in an air and moisture free environment, using Schlenk and glove-box techniques. The element-organic derivatives are used as ligands to obtain new coordination compounds as well as precursors for materials with controlled properties. Apart from the Schlenk-lines, the laboratory is equipped with a glove-box, and high purity solvents are obtained with an MBraun Automated Purifying System.

Team leader, Contact person: Assoc. Prof.dr. Gabriela Nemes, Email: sgabi@chem.ubbcluj.ro

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Biological Inorganic Chemistry

The analyses involve properties of inorganic, bioinorganic and biochemical systems with respect to reactivity and mechanisms of synthesis and decay, especially with relevance to oxidative and nitrosative stress, free radicals, and unusual coordination and valence states. These include laboratory-scale cultivation of simple organisms (recombinant overexpression of proteins in E. coli, fungal cultures, and others), purification and isolation of proteins from native and recombinant sources, biochemical and spectroscopic characterization (UV-vis, EPR), fast kinetics (stopped-flow UV-vis, freeze-quench for low-temperature EPR), general electron paramagnetic resonance (EPR including CW as well as pulsed techniques, at room temperature as well as down to 4 K) analyses, characterization of pro-oxidant and antioxidant properties of natural extracts (including development of methodology for assays, and exploration of chemical mechanisms), molecular modeling.

Team leader, Contact person: Assoc. Prof.dr. Radu Silaghi-Dumitrescu, Email: rsilaghi@chem.ubbcluj.ro

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