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Web of knowledge for DONTAS Contract number 171 National Authority: UEFISCDI |
UNIVERSITATEA BABES BOLYAI FACULTATEA DE CHIMIE SI INGINERIE CHIMICA
Development of new tools and smart Composites based on advanced nanotehnology FOR medical applications
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· National Authority: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI).
· Project leader: Prof. univ. dr. Maria Tomoaia-Cotisel (email: mcotisel@chem.ubbcluj.ro)
· Abstract
DONTAS project presents the research, development and innovation of new tools, like surgical methods and techniques by using metal implants coated with smart composite layers based on advanced nanotechnology for medical applications. More specific, nanostructured phosphates (nanoPHOs), such as nano hydroxyapatite (nanoHAP) incorporating different additions of silicon as an osseopromotive agent, as well as magnesium and zinc requested for bone metabolism are synthesized and structural, morphological and biological characterized. Further smart composites, made of said nanoPHOs incorporated into natural polymers (collagen type I and/or chitosan) are developed to mimic the characteristics of natural bone. In addition, nanoPHOs are incorporated into synthetic polymers (PMMA or poly-Bis-GMA) for comparison with the above ones. Our preliminary results indicate a remarkably difference among morphologies of various DONTAS composites ranging from particulate matters to fibers mineralized with nanoPHOs. Also, metal implants are realized by a strong cooperation in DONTAS consortium, formed of two prestigious universities and two important national institutes, as well as a small and medium sized enterprise (SME). The metal implants are advanced processed to reach the surface characteristics to be well osteo integrated in bone. Furthermore, the surface of implants is functionalized by coating with DONTAS composite layers to efficiently promote the bond of the implant to the bone. This inventive project tackles the bioactivity of the above new composites assembled as scaffolds on implants (rods, intramedullary rods or plates), which will be thoroughly examined in cell cultures of osteoblasts. DONTAS surgical tools and smart composites will have large medical applications for repairing and replacement of bone in orthopedic surgery and in reconstructive medicine.
· Project Consortium
CO – Babes-Bolyai University of Cluj-Napoca P1 - Iuliu Hatieganu University of Medicine and Pharmacy of Cluj-Napoca P2 - National Institute for Research and Development on Isotopic and Molecular Technologies, Cluj-Napoca P3 - Research Institute for Analytical Instrumentation, Cluj-Napoca P4 - Benerom Construct S.R.L., Cluj-Napoca
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