Web of knowledge for

INA - MAT

Contract number PCE 186 /2021

National Authority: UEFISCDI

UNIVERSITATEA BABES BOLYAI

FACULTATEA DE CHIMIE SI INGINERIE CHIMICA

Innovative strategies for safe production of advanced materials based on multifunctional ceramic and metallic nanoparticles for medical applications (INA-MAT)
Strategii inovative de producere a unor materiale avansate pe baza de nanoparticule, ceramice si metalice, multifunctionale pentru aplicatii medicale,
INA-MAT
 

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OBJECTIVES

EXPECTED RESULTS

OBTAINED RESULTS

DISSEMINATION

PCAS

·   National Authority: Executive Unit for Financing Higher Education,

                                      Research, Development and Innovation (UEFISCDI).

·   Contract number: PCE 186/2021

·   Project code: PN-III-P4-ID-PCE-2020-1910

·   Project leader:  Prof. Dr. Maria Tomoaia-Cotisel

         (email: maria.tomoaia@ubbcluj.ro; mcotisel@gmail.com)

CO – Babes-Bolyai University of Cluj-Napoca

              http://www.ubbcluj.ro

Abstract

INA-MAT project is focused on three topical scientific fields in current nanomedicine related to the use of metallic nanoparticles, NPs, of various controlled size, shape, surface area and surface structure modified by complexation with drugs:
(1) for targeted delivery of anti-cancer drugs, ACD, to cervical and bone cancer, and of anti-microbial compounds, AMC, targeted to bone infections. In this regard, metallic NPs, are functionalized with ACD, resulting NPs-ACD nano-complexes and functionalized with AMC, resulting NPs-AMC, nano-complexes.
(2) the combined metallic NPs-drug complexes with hydroxyapatite nanoparticles, HAP, or with multi-substituted HAP, ms-HAP, used as carriers are prepared leading to innovative nanomaterials for local drug delivery to bone regeneration.
(3) NPs-AMC nano-complexes and ceramic nanoparticles, jointly embedded into polymer matrix, resulting in nano-composites for sustained drug release at the place of action, enhancing local drug delivery to bone infection.