Research topics

Our past and current research has been focused on several enzyme classes such as lipases, esterases, oxidoreductases, aromatic ammonia-lyases and aminomutases, ω-transaminases, carboxylic acid decarboxylases.

The research activity at the Enzymology and Applied Biocatalysis Research Center is aimed at:

 

▶ Enzyme engineering through rational design and directed evolution tehniques

 

ACS Catal., 2019, 9: 8825.

Sci. Rep., 2019, 9: 647.
 

▶ Enzyme assay developments

 

Sci. Rep., 2020, 10: 18418. | Biomolecules, 2020, 10: 838. | Sci. Rep., 2022, 12(1): 3347.

 

▶ Enzyme immobilisation including support and method developments

 

React. Chem. Eng., 2018, 3: 790.

ChemCatChem, 2015, 7: 1122.
 

Catal. Sci. Technol., 2021, 11(16): 5553.
 

▶ Process engineering for biocatalytic production of synthetically valuable compounds

 

ACS Sustain. Chem. Eng., 2022, 9(15): 5461.

ACS Sustain. Chem. Eng., 2018, 6: 11353.

ACS Sustain. Chem. Eng., 2020, 8(3): 1611.

Org. Lett., 2018, 20: 8052.
 

▶ Batch, continuous-flow, micro-flow enzymatic and/or chemoenzymatic processes

 

ChemCatChem, 2011, 3: 343.

J. Flow. Chem., 2016, 6: 43.
 
 

ChemBioChem, 2015, 16: 2283.
 

▶ NEW! Antibiotic development by targeting bacterial enzymes

 

The structural facets and modulation/inhibition of the essential bacterial enzymes, and enzyme involving-PPIs, involved in the assembly of bacterial cell envelope: the YejM-LapB-FtsH-LpxC protein network and the DprE1-DprE2 protein complex are among our studied targets.
See for details the BACPROBIO project