Contract: 91TE/03.01.2025
Design of organotin(IV) chalcogenide clusters as building blocks for metal organometallic networks
Design of organotin(IV) chalcogenide clusters as building blocks for metal organometallic networks
Project timespan
2025 -- 2026
2025 -- 2026
Abstract
The aim of the current project proposal is the development of a new generation of organotin(IV) chalcogenide clusters with the general formula [(RSn)4E6] E = S, Se, Te, decorated with functional aryl fragments (i.e. R = -C6H4-CHO, -C6H4-COOH, -C6H4-CN, -C6H4-CH=NR’) and their usage as linkers for metal-organometallic networks (MOMNs). This includes the synthesis and structural characterization of the designed species; in addition, the optical properties, single-source precursor potential, and biological (cytotoxicity, antitumor, apoptosis, and autophagy assay) activity for selected compounds will also be studied. The following objectives (O) will be developed:
O1. Access to aryltin(IV) di- and trichlorides decorated with ortho-functionalized organic fragments.
O2. Access to aryltin(IV) di- and trichlorides decorated with para-functionalized organic fragments.
O3. Design and synthesis of organotin(IV) chalcogenides clusters.
O4. Investigation of the coordination abilities of the organotin(IV) chalcogenides clusters.
O5. Structural investigation of the isolated compounds.
O6. Studies on the cytotoxicity and optical properties of the organotin(IV) species.
The novelty elements include the evaluation of the unexplored coordination potential for the functionalized organotin(IV) clusters to generate MOMNs and the investigation of the cooperative effect between Sn and different chalcogenides in terms of biological activity, catalytic and optical properties.
The aim of the current project proposal is the development of a new generation of organotin(IV) chalcogenide clusters with the general formula [(RSn)4E6] E = S, Se, Te, decorated with functional aryl fragments (i.e. R = -C6H4-CHO, -C6H4-COOH, -C6H4-CN, -C6H4-CH=NR’) and their usage as linkers for metal-organometallic networks (MOMNs). This includes the synthesis and structural characterization of the designed species; in addition, the optical properties, single-source precursor potential, and biological (cytotoxicity, antitumor, apoptosis, and autophagy assay) activity for selected compounds will also be studied. The following objectives (O) will be developed:
O1. Access to aryltin(IV) di- and trichlorides decorated with ortho-functionalized organic fragments.
O2. Access to aryltin(IV) di- and trichlorides decorated with para-functionalized organic fragments.
O3. Design and synthesis of organotin(IV) chalcogenides clusters.
O4. Investigation of the coordination abilities of the organotin(IV) chalcogenides clusters.
O5. Structural investigation of the isolated compounds.
O6. Studies on the cytotoxicity and optical properties of the organotin(IV) species.
The novelty elements include the evaluation of the unexplored coordination potential for the functionalized organotin(IV) clusters to generate MOMNs and the investigation of the cooperative effect between Sn and different chalcogenides in terms of biological activity, catalytic and optical properties.
Budget
| Budget chapter (expenses) | 2025 (lei) | 2026 (lei) | Total | |
|---|---|---|---|---|
| 1 | Salaries | 162,843 | 163,200 | 326,043 |
| 2 | Inventory | 56,414.01 | 24,850 | 81,264.01 |
| 3 | Mobility | 2,388.03 | 12,000 | 14,388.03 |
| 4 | Overhead | 40,794.96 | 37,510 | 78,304.96 |
| 5 | Total | 262,440 | 237,560 | 500,000 |
Results
Results January - December 2025
The first implementation stage of the project aimed the preparation and structural characterization (O5) of organotin(IV) di- and trichlorides decorated with ortho - (O1) and para-functionalized (O2) organic fragments and their use in the isolation of new organotin(IV) chalcogenides (O3).
Thus, a series of diorganotin(IV) dichlorides R2SnCl2 were obtained, three of which are new, and one organotin(IV) trichloride [2-(OCH)C6H4]SnCl3, which will be functionalized in the next stage and used to obtain chalcogenides. Starting from R2SnCl2 precursors, novel organotin(IV) chalcogenides were isolated, which exhibit a tetra-atomic Sn2E2 core, E = S, Se.
Several RSnBu3 precursors, decorated with various aromatic substituents, were also sysnthesized to be emplyed as starting materials for the preparation of organotin(IV) trihalides.
For the identification and characterization of the compounds multinuclear NMR (1H, 13C{1H}, 119Sn{1H}) spectroscopy, mass spectrometry and single-crystal X-ray diffraction were used.
Articles
Conferences
Results January - December 2025
The first implementation stage of the project aimed the preparation and structural characterization (O5) of organotin(IV) di- and trichlorides decorated with ortho - (O1) and para-functionalized (O2) organic fragments and their use in the isolation of new organotin(IV) chalcogenides (O3).
Thus, a series of diorganotin(IV) dichlorides R2SnCl2 were obtained, three of which are new, and one organotin(IV) trichloride [2-(OCH)C6H4]SnCl3, which will be functionalized in the next stage and used to obtain chalcogenides. Starting from R2SnCl2 precursors, novel organotin(IV) chalcogenides were isolated, which exhibit a tetra-atomic Sn2E2 core, E = S, Se.
Several RSnBu3 precursors, decorated with various aromatic substituents, were also sysnthesized to be emplyed as starting materials for the preparation of organotin(IV) trihalides.
For the identification and characterization of the compounds multinuclear NMR (1H, 13C{1H}, 119Sn{1H}) spectroscopy, mass spectrometry and single-crystal X-ray diffraction were used.
Articles
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Diaryltin(IV) chalcogenides decorated with functional ligands. Synthesis, structural characterization and reactivity.
Mihai Băla, Nora Chiorean, R. A. Varga, A.-A. Someșan, in preparation.
Conferences
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Synthesis, Characterization and Optical Properties of a New Organotin(IV) Schiff Base Complex,
Ana-Diana Petri, Adrian-A. Someșan,
at 21st International Conference ”Students for Students”, April 9-13, 2025. (poster presentation)
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Organotin(IV) chalcogenides – design, synthesis and applications,
Mihai Băla, Richard A. Varga, Adrian-A. Someșan,
at 3rd Main Group Metal Chemistry Symposium, Paris, France, November 12-13, 2025. (oral presentation)