Proiect PN-III-P1-1.1-PD-2019-0480:
Project timespan
Project team
Abstract
Project objectives
Budget
Results
Funding authority: Executive Agency for Higher Education, Research, Development and Innovation Funding Contract: PD 104/2020
Project timespan
2020-- 2022
2020-- 2022
Abstract
The project aims the development of exciting research in the field of Covalent Organic Frameworks (COFs) in order to fabricate innovative materials based on original COFs dedicated to smart applications in areas as drug delivery, gas and organic molecules absorption and separation, chiral separation and enantioselective catalysis. The originality of the proposed materials is ensured by the novelty and versatility of proposed substrates (e.g. derivatives of spiro-9,9’-bifluorene) and by the target reactions which are unexplored for the proposed substrates and reagents (e.g. cyano and boronic acid trimerizations, polyimide formation..). The original design of proposed porous materials is strongly correlated with the requests of the desired applications of COFs (the dimensions of the pores, the ability of different units to give specific contacts, stability, etc…). A high degree of novelty of our project is coming, also from our target to obtain COFs which incorporate enantiomerically pure chiral units and from the employment of these chiral COFs for chiral separations (resolution of racemics) and for enantioselective catalytic processes. The role of COFs in these applications is to ensure confined spaces during the contact of enantiomers (resolution of racemics) or prochiral molecules (in the enantioselective catalysis steps) with the chiral units of the COFs (selectors), and to dramatically increase the stereoselectivity of the processes.
The project aims the development of exciting research in the field of Covalent Organic Frameworks (COFs) in order to fabricate innovative materials based on original COFs dedicated to smart applications in areas as drug delivery, gas and organic molecules absorption and separation, chiral separation and enantioselective catalysis. The originality of the proposed materials is ensured by the novelty and versatility of proposed substrates (e.g. derivatives of spiro-9,9’-bifluorene) and by the target reactions which are unexplored for the proposed substrates and reagents (e.g. cyano and boronic acid trimerizations, polyimide formation..). The original design of proposed porous materials is strongly correlated with the requests of the desired applications of COFs (the dimensions of the pores, the ability of different units to give specific contacts, stability, etc…). A high degree of novelty of our project is coming, also from our target to obtain COFs which incorporate enantiomerically pure chiral units and from the employment of these chiral COFs for chiral separations (resolution of racemics) and for enantioselective catalytic processes. The role of COFs in these applications is to ensure confined spaces during the contact of enantiomers (resolution of racemics) or prochiral molecules (in the enantioselective catalysis steps) with the chiral units of the COFs (selectors), and to dramatically increase the stereoselectivity of the processes.
Main objectives
O1. Access to achiral COF and the determination of their properties (gas absorption, specific surfaces, pore dimensions, etc).
O2. Access to chiral COF and the determination of their properties (gas absorption, specific surfaces, pore dimensions, etc).
O3. Exploration of COFs with potential properties for drug-delivery and of COFs based selective membranes for gas and organic compounds separation.
O4. Exploration of enantioselective separation and catalysis properties of chiral COFs.
O5. Development of personal professional skills and improvement of the academic and research environment.
O1. Access to achiral COF and the determination of their properties (gas absorption, specific surfaces, pore dimensions, etc).
O2. Access to chiral COF and the determination of their properties (gas absorption, specific surfaces, pore dimensions, etc).
O3. Exploration of COFs with potential properties for drug-delivery and of COFs based selective membranes for gas and organic compounds separation.
O4. Exploration of enantioselective separation and catalysis properties of chiral COFs.
O5. Development of personal professional skills and improvement of the academic and research environment.
Budget
| Budget chapter (expenses) | 2020 (lei) | 2021 (lei) | 2022 (lei) | Total | |
|---|---|---|---|---|---|
| 1 | Salaries | 28.000 | 98.689 | 56.000 | 182.689 |
| 2 | Inventory | 6.000 | 2.166 | 6.459 | 14.625 |
| 3 | Mobility | 0 | 5.145 | 5.000 | 10.145 |
| 4 | Overhead | 6.800 | 19.200 | 13.491 | 39.491 |
| 5 | Total | 40.800 | 125.200 | 80.950 | 246.950 |
Results
Contributions to BSc Theses
Reports
Contributions to BSc Theses
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Jurca R.-M, Tehnologia de sinteză a unui COF cu aplicații în biomedicină și cataliză. Universitatea Babeş-Bolyai, Cluj-Napoca, Iunie 2021.
- Sonogashira Synthesis of New Porous Aromatic Framework-Entrapped Palladium Nanoparticles as Heterogeneous Catalysts for Suzuki−Miyaura Cross-Coupling
L. Căta, N. Terenti, C. Cociug, N. D. Hădade, I. Grosu, C. Bucur, B. Cojocaru, V. I. Parvulescu, M. Mazur, J. Čejka, ACS Appl. Mater. Interfaces, 2022, 14, 10428−10437.
DOI: 10.1021/acsami.1c24429
Reports
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The yearly scientific reports containing experimental details of unpublished compounds data can be provided for project evaluation purposes only. Assist. Prof. Dr. Lidia Căta (née Pop) at lidia.pop@ubbcluj.ro.